Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells

Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells

When cells acquire a malignant phenotype they become less stiff and this helps migration and invasion favouring metastasis. Here the authors show that Src-driven cell transformation and transition to a less stiff state follows an event of membrane stiffening due to stress fibres accumulation.

Bibliographic Details
Main Authors: Sandra Tavares, André Filipe Vieira, Anna Verena Taubenberger, Margarida Araújo, Nuno Pimpao Martins, Catarina Brás-Pereira, António Polónia, Maik Herbig, Clara Barreto, Oliver Otto, Joana Cardoso, José B. Pereira-Leal, Jochen Guck, Joana Paredes, Florence Janody
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15237

Internet

https://doi.org/10.1038/ncomms15237

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