Nf1 Loss and Ras Hyperactivation in Oligodendrocytes Induce NOS-Driven Defects in Myelin and Vasculature

Nf1 Loss and Ras Hyperactivation in Oligodendrocytes Induce NOS-Driven Defects in Myelin and Vasculature

Patients with neurofibromatosis type 1 (NF1) and Costello syndrome Rasopathy have behavioral deficits. In NF1 patients, these may correlate with white matter enlargement and aberrant myelin. To model these features, we induced Nf1 loss or HRas hyperactivation in mouse oligodendrocytes. Enlarged bra...

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Bibliographic Details
Main Authors: Debra A. Mayes, Tilat A. Rizvi, Haley Titus-Mitchell, Rachel Oberst, Georgianne M. Ciraolo, Charles V. Vorhees, Andrew P. Robinson, Stephen D. Miller, Jose A. Cancelas, Anat O. Stemmer-Rachamimov, Nancy Ratner
Format: Article
Language:English
Published: Elsevier 2013-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471300435X

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http://www.sciencedirect.com/science/article/pii/S221112471300435X

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