Understanding the Significance and Implications of Antibody Numbering and Antigen-Binding Surface/Residue Definition

Understanding the Significance and Implications of Antibody Numbering and Antigen-Binding Surface/Residue Definition

Monoclonal antibodies are playing an increasing role in both human and animal health. Different strategies of protein and chemical engineering, including humanization techniques of non-human antibodies were applied successfully to optimize clinical performances of antibodies. Despite the emergence o...

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Bibliographic Details
Main Authors: Mathieu Dondelinger, Patrice Filée, Eric Sauvage, Birgit Quinting, Serge Muyldermans, Moreno Galleni, Marylène S. Vandevenne
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
numbering scheme
complementary determining regions
antibody humanization
antigen binding residue
antibody engineering
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02278/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02278/full

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