Oxyberberine, an absorbed metabolite of berberine, possess superior hypoglycemic effect via regulating the PI3K/Akt and Nrf2 signaling pathways

Oxyberberine, an absorbed metabolite of berberine, possess superior hypoglycemic effect via regulating the PI3K/Akt and Nrf2 signaling pathways

Berberine (BBR) is a promising anti-diabetic isoquinoline alkaloid from Rhizoma coptidis, while its bioavailability was extremely low. Here, the existing form and pharmacokinetics of BBR were comparatively characterized in conventional and antibiotic-induced pseudo germ-free (PGF) rats. Furthermore,...

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Bibliographic Details
Main Authors: Yaoxing Dou, Ronglei Huang, Qiaoping Li, Yuhong Liu, Yucui Li, Hanbin Chen, Gaoxiang Ai, Jianhui Xie, Huifang Zeng, Jiannan Chen, Chaodan Luo, Ziren Su
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Oxyberberine
Berberine
Metabolite
Oxidative stress and inflammation
Diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221000974

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http://www.sciencedirect.com/science/article/pii/S0753332221000974

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