TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease

TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease

Aortic valve disease (AVD) is characterized by elastic fiber fragmentation (EFF), fibrosis and aberrant angiogenesis. Emilin1 is an elastin-binding glycoprotein that regulates elastogenesis and inhibits TGF-β signaling, but the role of Emilin1 in valve tissue is unknown. We tested the hypothesis tha...

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Bibliographic Details
Main Authors: Charu Munjal, Amy M. Opoka, Hanna Osinska, Jeanne F. James, Giorgio M. Bressan, Robert B. Hinton
Format: Article
Language:English
Published: The Company of Biologists 2014-08-01
Series:Disease Models & Mechanisms
Subjects:
Elastic fibers
Extracellular matrix
Aortic valve
Fibrosis
Angiogenesis
Online Access:http://dmm.biologists.org/content/7/8/987

Internet

http://dmm.biologists.org/content/7/8/987

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