Pre-existing Immunity to Japanese Encephalitis Virus Alters CD4 T Cell Responses to Zika Virus Inactivated Vaccine

Pre-existing Immunity to Japanese Encephalitis Virus Alters CD4 T Cell Responses to Zika Virus Inactivated Vaccine

The epidemic spread of Zika virus (ZIKV), associated with devastating neurologic syndromes, has driven the development of multiple ZIKV vaccines candidates. An effective vaccine should induce ZIKV-specific T cell responses, which are shown to improve the establishment of humoral immunity and contrib...

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Bibliographic Details
Main Authors: Noemia S. Lima, Damee Moon, Samuel Darko, Rafael A. De La Barrera, Leyi Lin, Michael A. Koren, Richard G. Jarman, Kenneth H. Eckels, Stephen J. Thomas, Nelson L. Michael, Kayvon Modjarrad, Daniel C. Douek, Lydie Trautmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
zika virus
vaccine
flavivirus
CD4 T cell
cross-reactivity
TCR repertoire
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.640190/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.640190/full

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