Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis.

Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis.

A number of constitutively activated signaling pathways play critical roles in the survival and growth of primary effusion lymphoma cells (PELs) including NFkB and PI3/AKT kinase cascades. NFkBis constitutively activated in a number of malignancies, including multiple myeloma, Burkitt's lymphom...

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Bibliographic Details
Main Authors: Azhar R Hussain, Saeeda O Ahmed, Maqbool Ahmed, Omar S Khan, Sally Al Abdulmohsen, Leonidas C Platanias, Khawla S Al-Kuraya, Shahab Uddin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3386924?pdf=render

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http://europepmc.org/articles/PMC3386924?pdf=render

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