Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection.

Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection.

CD8+ T cells impact control of viral infections by direct elimination of infected cells and secretion of a number of soluble factors. In HIV-1 infection, persistent HIV-1 specific IFN-gamma+ CD8+ T cell responses are detected in the setting of disease progression, consistent with functional impairme...

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Bibliographic Details
Main Authors: Marylyn M Addo, Rika Draenert, Almas Rathod, Cori L Verrill, Benjamin T Davis, Rajesh T Gandhi, Gregory K Robbins, Nesli O Basgoz, David R Stone, Daniel E Cohen, Mary N Johnston, Theresa Flynn, Alysse G Wurcel, Eric S Rosenberg, Marcus Altfeld, Bruce D Walker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1824710?pdf=render

Internet

http://europepmc.org/articles/PMC1824710?pdf=render

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