Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia

Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia

Trefoil factor 1 (TFF1) is a protein secreted by the gastric mucosa that protects against gastric tumourigenesis. Here, the authors show that TFF1 inhibits the oncogenic inflammatory response and IL-6-mediated STAT3 activation by interfering with the binding of IL6 to its receptor IL6Rα.

Bibliographic Details
Main Authors: Mohammed Soutto, Zheng Chen, Ajaz A. Bhat, Lihong Wang, Shoumin Zhu, Ahmed Gomaa, Andreia Bates, Nadeem S. Bhat, Dunfa Peng, Abbes Belkhiri, M. Blanca Piazuelo, M. Kay Washington, Xi Chen Steven, Richard Peek, Wael El-Rifai
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11011-4

Internet

https://doi.org/10.1038/s41467-019-11011-4

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