2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes BHV-1 infection in mammalian cells by interfering with iron homeostasis regulation.

2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes BHV-1 infection in mammalian cells by interfering with iron homeostasis regulation.

Mammalian cells require iron to satisfy metabolic needs or to accomplish specialized functions, and DNA viruses, like bovine herpesvirus 1 (BHV-1), require an iron-replete host to efficiently replicate, so that iron bioavailability is an important component of viral virulence. Cellular iron metaboli...

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Bibliographic Details
Main Authors: Filomena Fiorito, Carlo Irace, Antonio Di Pascale, Alfredo Colonna, Giuseppe Iovane, Ugo Pagnini, Rita Santamaria, Luisa De Martino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3592816?pdf=render

Internet

http://europepmc.org/articles/PMC3592816?pdf=render

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