All-trans retinoic acid suppresses the adhering ability of ARPE-19 cells via mitogen-activated protein kinase and focal adhesion kinase

All-trans retinoic acid suppresses the adhering ability of ARPE-19 cells via mitogen-activated protein kinase and focal adhesion kinase

This study investigated the signaling mechanism underlying the anti-adhesive effect of all-trans retinoic acid (ATRA) on retinal pigment epithelial ARPE-19 cells. Adhesion kinetics with or without ATRA treatment were profiled by adhesion assay. Surface coating with type IV collagen, fibronectin, lam...

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Bibliographic Details
Main Authors: Yo-Chen Chang, Yuh-Shin Chang, Ming-Chu Hsieh, Horng-Jiun Wu, Meng-Hsien Wu, Chia-Wei Lin, Wen-Chuan Wu, Ying-Hsien Kao
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Journal of Pharmacological Sciences
Subjects:
Extracellular matrix
Fibronectin
Focal adhesion kinase
Mitogen-activated protein kinase
PI3K inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316301505

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http://www.sciencedirect.com/science/article/pii/S1347861316301505

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