Genetic determinants for methotrexate response in juvenile idiopathic arthritis

Genetic determinants for methotrexate response in juvenile idiopathic arthritis

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of childhood and is an important cause of disability. The folic acid analogue methotrexate is the first choice disease-modifying anti-rheumatic drug in this disease, however, 35-45% of patients fail to respond. Molecula...

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Bibliographic Details
Main Authors: Serena ePastore, Gabriele eStocco, Diego eFavretto, Sara eDe Iudicibus, Andrea eTaddio, Pio ed'Adamo, Riccardo eAddobbati, Giuliana eDecorti, Loredana eLepore, Alessandro eVentura
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Pharmacology
Subjects:
Gene Expression Profiling
Genome-Wide Association Study
Methotrexate
pharmacogenomics
juvenile idiopathic arthritis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00052/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00052/full

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