Blockade of adenosine A2A receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons

Blockade of adenosine A2A receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons

Since adenosine A2A receptor (A2ARs) blockade protects against noxious brain insults involving apoptosis, we directly tested if A2AR blockade prevents apoptosis induced by staurosporine (STS). Exposure of rat hippocampal neurons to STS (30 nM, 24 h) decreased neuronal viability while increasing the...

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Bibliographic Details
Main Authors: Carla G. Silva, Lisiane O. Porciúncula, Paula M. Canas, Catarina R. Oliveira, Rodrigo A. Cunha
Format: Article
Language:English
Published: Elsevier 2007-08-01
Series:Neurobiology of Disease
Subjects:
Adenosine
A2A receptor
Staurosporine
Apoptosis
Neuroprotection
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610700085X

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http://www.sciencedirect.com/science/article/pii/S096999610700085X

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