Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

The nucleolus is a membrane-less organelle formed through liquid-liquid phase separation of its components from the surrounding nucleoplasm. Here, we show that nucleophosmin (NPM1) integrates within the nucleolus via a multi-modal mechanism involving multivalent interactions with proteins containing...

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Bibliographic Details
Main Authors: Diana M Mitrea, Jaclyn A Cika, Clifford S Guy, David Ban, Priya R Banerjee, Christopher B Stanley, Amanda Nourse, Ashok A Deniz, Richard W Kriwacki
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
nucleolus
phase separation
NPM1/B23/nucleophosmin
nucleolar localization
intrinsically disordered proteins
single molecule fluorescence
Online Access:https://elifesciences.org/articles/13571

Internet

https://elifesciences.org/articles/13571

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