Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA

Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA

Alphaviruses need to selectively package genomic viral RNA for transmission, but the packaging mechanism remains unclear. Here, Brown et al. combine PAR-CLIP with biotinylated capsid protein (Cp) retrieval and identify multiple Cp binding sites on genomic viral RNA that promote virion formation.

Bibliographic Details
Main Authors: Rebecca S. Brown, Dimitrios G. Anastasakis, Markus Hafner, Margaret Kielian
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18447-z

Internet

https://doi.org/10.1038/s41467-020-18447-z

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