Progression of cartilage degradation, bone resorption and pain in rat temporomandibular joint osteoarthritis induced by injection of iodoacetate.

BACKGROUND: Osteoarthritis (OA) is an important subtype of temporomandibular disorders. A simple and reproducible animal model that mimics the histopathologic changes, both in the cartilage and subchondral bone, and clinical symptoms of temporomandibular joint osteoarthritis (TMJOA) would help in ou...

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Main Authors: Xue-Dong Wang, Xiao-Xing Kou, Dan-Qing He, Min-Min Zeng, Zhen Meng, Rui-Yun Bi, Yan Liu, Jie-Ni Zhang, Ye-Hua Gan, Yan-Heng Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3439407?pdf=render