The Link of the Prion Protein with Ca<sup>2+</sup> Metabolism and ROS Production, and the Possible Implication in Aβ Toxicity

The Link of the Prion Protein with Ca<sup>2+</sup> Metabolism and ROS Production, and the Possible Implication in Aβ Toxicity

The cellular prion protein (PrP<sup>C</sup>) is an ubiquitous cell surface protein mostly expressed in neurons, where it localizes to both pre- and post-synaptic membranes. PrP<sup>C</sup> aberrant conformers are the major components of mammalian prions, the infectious agents...

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Bibliographic Details
Main Authors: Agnese De Mario, Caterina Peggion, Maria Lina Massimino, Rosa Pia Norante, Alessandra Zulian, Alessandro Bertoli, Maria Catia Sorgato
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
prion protein
Ca<sup>2+</sup> homeostasis
glutamate
neurotransmission
synapses
ROS
Aβ oligomers
Fyn
NADPH oxidase
Online Access:https://www.mdpi.com/1422-0067/20/18/4640

Internet

https://www.mdpi.com/1422-0067/20/18/4640

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