The Link of the Prion Protein with Ca<sup>2+</sup> Metabolism and ROS Production, and the Possible Implication in Aβ Toxicity
The cellular prion protein (PrP<sup>C</sup>) is an ubiquitous cell surface protein mostly expressed in neurons, where it localizes to both pre- and post-synaptic membranes. PrP<sup>C</sup> aberrant conformers are the major components of mammalian prions, the infectious agents...
Main Authors: | Agnese De Mario, Caterina Peggion, Maria Lina Massimino, Rosa Pia Norante, Alessandra Zulian, Alessandro Bertoli, Maria Catia Sorgato |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-09-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/20/18/4640 |
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