Reduction of Superoxide Dismutase 1 Delays Regeneration of Cardiotoxin-Injured Skeletal Muscle in KK/Ta-<i>Ins2<sup>Akita</sup></i> Mice with Progressive Diabetic Nephropathy

Reduction of Superoxide Dismutase 1 Delays Regeneration of Cardiotoxin-Injured Skeletal Muscle in KK/Ta-<i>Ins2<sup>Akita</sup></i> Mice with Progressive Diabetic Nephropathy

Superoxide dismutase (SOD) is a major antioxidant enzyme for superoxide removal, and cytoplasmic SOD (SOD1) is expressed as a predominant isoform in all cells. We previously reported that renal SOD1 deficiency accelerates the progression of diabetic nephropathy (DN) via increasing renal oxidative st...

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Bibliographic Details
Main Authors: Yuya Takahashi, Tatsunori Shimizu, Shunsuke Kato, Mitsuhiko Nara, Yumi Suganuma, Takehiro Sato, Tsukasa Morii, Yuichiro Yamada, Hiroki Fujita
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
akita mouse
cardiotoxin injury
diabetic nephropathy
muscle regeneration
oxidative stress
superoxide dismutase 1
Online Access:https://www.mdpi.com/1422-0067/22/11/5491

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https://www.mdpi.com/1422-0067/22/11/5491

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