Elevation of miR-302b prevents multiple myeloma cell growth and bone destruction by blocking DKK1 secretion

Elevation of miR-302b prevents multiple myeloma cell growth and bone destruction by blocking DKK1 secretion

Abstract Background Myeloma bone disease (MBD) is a severe complication of multiple myeloma (MM) mainly due to an imbalance between enhanced osteoclast activity and reduced osteoblast function. Previous studies have demonstrated that miRNAs play a vital role in the osteogenic differentiation of mese...

Full description

Bibliographic Details
Main Authors: Zheyu Wu, Yufeng Zhang, Zhiqiang Yang, Yufan Zhu, Yuanlong Xie, Fuling Zhou, Lin Cai
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Cancer Cell International
Subjects:
Multiple myeloma
Myeloma bone disease
miR-302b
DKK1
Online Access:https://doi.org/10.1186/s12935-021-01887-y

Internet

https://doi.org/10.1186/s12935-021-01887-y

Similar Items