Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

Here, using lung epithelial cells and ex vivo tissue explants, the authors show that, in addition to ACE2, host heparan sulfate is directly involved in SARS-CoV-2 attachment and entry and provide data suggesting that host sialic acids may act as viral restriction factor in lung tissues.

Bibliographic Details
Main Authors:	Hin Chu, Bingjie Hu, Xiner Huang, Yue Chai, Dongyan Zhou, Yixin Wang, Huiping Shuai, Dong Yang, Yuxin Hou, Xi Zhang, Terrence Tsz-Tai Yuen, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Kelvin Kai-Wang To, Ivy Hau-Yee Chan, Ko-Yung Sit, Dominic Chi-Chung Foo, Ian Yu-Hong Wong, Ada Tsui-Lin Ng, Tan To Cheung, Simon Ying-Kit Law, Wing-Kuk Au, Melinda A. Brindley, Zhiwei Chen, Kin-Hang Kok, Jasper Fuk-Woo Chan, Kwok-Yung Yuen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-20457-w

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spelling	doaj-81bdbff8c7524b069f430bb69d6fb8112021-01-10T12:19:44ZengNature Publishing GroupNature Communications2041-17232021-01-0112111510.1038/s41467-020-20457-wHost and viral determinants for efficient SARS-CoV-2 infection of the human lungHin Chu0Bingjie Hu1Xiner Huang2Yue Chai3Dongyan Zhou4Yixin Wang5Huiping Shuai6Dong Yang7Yuxin Hou8Xi Zhang9Terrence Tsz-Tai Yuen10Jian-Piao Cai11Anna Jinxia Zhang12Jie Zhou13Shuofeng Yuan14Kelvin Kai-Wang To15Ivy Hau-Yee Chan16Ko-Yung Sit17Dominic Chi-Chung Foo18Ian Yu-Hong Wong19Ada Tsui-Lin Ng20Tan To Cheung21Simon Ying-Kit Law22Wing-Kuk Au23Melinda A. Brindley24Zhiwei Chen25Kin-Hang Kok26Jasper Fuk-Woo Chan27Kwok-Yung Yuen28State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong KongState Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong KongState Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong KongState Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong KongState Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Infectious Diseases, Department of Population Health, College of Veterinary Medicine, University of GeorgiaState Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong KongState Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong KongState Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong KongState Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong KongHere, using lung epithelial cells and ex vivo tissue explants, the authors show that, in addition to ACE2, host heparan sulfate is directly involved in SARS-CoV-2 attachment and entry and provide data suggesting that host sialic acids may act as viral restriction factor in lung tissues.https://doi.org/10.1038/s41467-020-20457-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hin Chu Bingjie Hu Xiner Huang Yue Chai Dongyan Zhou Yixin Wang Huiping Shuai Dong Yang Yuxin Hou Xi Zhang Terrence Tsz-Tai Yuen Jian-Piao Cai Anna Jinxia Zhang Jie Zhou Shuofeng Yuan Kelvin Kai-Wang To Ivy Hau-Yee Chan Ko-Yung Sit Dominic Chi-Chung Foo Ian Yu-Hong Wong Ada Tsui-Lin Ng Tan To Cheung Simon Ying-Kit Law Wing-Kuk Au Melinda A. Brindley Zhiwei Chen Kin-Hang Kok Jasper Fuk-Woo Chan Kwok-Yung Yuen
spellingShingle	Hin Chu Bingjie Hu Xiner Huang Yue Chai Dongyan Zhou Yixin Wang Huiping Shuai Dong Yang Yuxin Hou Xi Zhang Terrence Tsz-Tai Yuen Jian-Piao Cai Anna Jinxia Zhang Jie Zhou Shuofeng Yuan Kelvin Kai-Wang To Ivy Hau-Yee Chan Ko-Yung Sit Dominic Chi-Chung Foo Ian Yu-Hong Wong Ada Tsui-Lin Ng Tan To Cheung Simon Ying-Kit Law Wing-Kuk Au Melinda A. Brindley Zhiwei Chen Kin-Hang Kok Jasper Fuk-Woo Chan Kwok-Yung Yuen Host and viral determinants for efficient SARS-CoV-2 infection of the human lung Nature Communications
author_facet	Hin Chu Bingjie Hu Xiner Huang Yue Chai Dongyan Zhou Yixin Wang Huiping Shuai Dong Yang Yuxin Hou Xi Zhang Terrence Tsz-Tai Yuen Jian-Piao Cai Anna Jinxia Zhang Jie Zhou Shuofeng Yuan Kelvin Kai-Wang To Ivy Hau-Yee Chan Ko-Yung Sit Dominic Chi-Chung Foo Ian Yu-Hong Wong Ada Tsui-Lin Ng Tan To Cheung Simon Ying-Kit Law Wing-Kuk Au Melinda A. Brindley Zhiwei Chen Kin-Hang Kok Jasper Fuk-Woo Chan Kwok-Yung Yuen
author_sort	Hin Chu
title	Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
title_short	Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
title_full	Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
title_fullStr	Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
title_full_unstemmed	Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
title_sort	host and viral determinants for efficient sars-cov-2 infection of the human lung
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-01-01
description	Here, using lung epithelial cells and ex vivo tissue explants, the authors show that, in addition to ACE2, host heparan sulfate is directly involved in SARS-CoV-2 attachment and entry and provide data suggesting that host sialic acids may act as viral restriction factor in lung tissues.
url	https://doi.org/10.1038/s41467-020-20457-w
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Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

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