H2O2‐induced microvessel barrier dysfunction: the interplay between reactive oxygen species, nitric oxide, and peroxynitrite

Abstract Elevated H2O2 is implicated in many cardiovascular diseases. We previously demonstrated that H2O2‐induced endothelial nitric oxide synthase (eNOS) activation and excessive NO production contribute to vascular cell injury and increases in microvessel permeability. However, the mechanisms of...

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Bibliographic Details
Main Authors: Xueping Zhou, Yan Qian, Dong Yuan, Qilong Feng, Pingnian He
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.14206