Region-based interaction detection in genome-wide case-control studies

Abstract Background In genome-wide association study (GWAS), conventional interaction detection methods such as BOOST are mostly based on SNP-SNP interactions. Although single nucleotides are the building blocks of human genome, single nucleotide polymorphisms (SNPs) are not necessarily the smallest...

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Bibliographic Details
Main Authors: Sen Zhang, Wei Jiang, Ronald CW Ma, Weichuan Yu
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Medical Genomics
Subjects:
Online Access:https://doi.org/10.1186/s12920-019-0583-7