The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance

The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance

Abstract Background The dynamics of histone post-translational modifications (PTMs) are sparsely described, especially in their true physiological context of proteoforms (single histone molecules harboring combinations of PTMs). Methods Here we time-resolve the response of cells to SUV4-20 methyltra...

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Bibliographic Details
Main Authors: Tao Wang, Matthew V. Holt, Nicolas L. Young
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Epigenetics & Chromatin
Subjects:
Histone methyltransferase
SUV4-20
Histone post-translational modifications
Epigenetic inhibitor
Breast cancer
Top-down proteomics
Online Access:http://link.springer.com/article/10.1186/s13072-018-0198-9

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http://link.springer.com/article/10.1186/s13072-018-0198-9

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