α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast

α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast

Parkinson’s disease (PD) is the most prevalent movement disorder characterized with loss of dopaminergic neurons in the brain. One of the pathological hallmarks of the disease is accumulation of aggregated α-synuclein (αSyn) in cytoplasmic Lewy body inclusions that indicates significant dysfunction...

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Bibliographic Details
Main Authors: Blagovesta Popova, Dajana Galka, Nicola Häffner, Dan Wang, Kerstin Schmitt, Oliver Valerius, Michael Knop, Gerhard H. Braus
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
alpha-synuclein
Parkinson disease
protein aggregation
yeast
ubiquitin–proteasome system
protein homeostasis
Online Access:https://www.mdpi.com/2073-4409/10/9/2229

Internet

https://www.mdpi.com/2073-4409/10/9/2229

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