Three-Dimensional Study of Alzheimer’s Disease Hallmarks Using the iDISCO Clearing Method

Three-Dimensional Study of Alzheimer’s Disease Hallmarks Using the iDISCO Clearing Method

Amyloidosis is a major problem in over one hundred diseases, including Alzheimer’s disease (AD). Using the iDISCO visualization method involving targeted molecular labeling, tissue clearing, and light-sheet microscopy, we studied plaque formation in the intact AD mouse brain at up to 27 months of ag...

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Bibliographic Details
Main Authors: Thomas Liebmann, Nicolas Renier, Karima Bettayeb, Paul Greengard, Marc Tessier-Lavigne, Marc Flajolet
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Cell Reports
Subjects:
amyloid plaques
tau
iDISCO
brain clearing
Alzheimer’s disease
amyloidosis
3D amyloid patterns (TAPs)
Congo red
3D rendering
microglia
ClearMap
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716308142

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http://www.sciencedirect.com/science/article/pii/S2211124716308142

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