Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3

Galectin-3 consists of an unstructured N-terminal domain (NTD) and a structured carbohydrate-recognition domain and agglutinates neutrophils and glycosylated molecules in the extracellular milieu. Here the authors combine biophysical and biochemical experiments with NMR measurements and show that th...

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Bibliographic Details
Main Authors: Yi-Ping Chiu, Yung-Chen Sun, De-Chen Qiu, Yu-Hao Lin, Yin-Quan Chen, Jean-Cheng Kuo, Jie-rong Huang
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15007-3