Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC

Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC

Mathematical models of biochemical networks form a cornerstone of bacterial systems biology. Inconsistencies between simulation output and experimental data point to gaps in knowledge about the fundamental biology of the organism. One such inconsistency centers on the gene aldA in Escherichia coli...

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Bibliographic Details
Main Authors: Ramy Karam Aziz, Valerie eKhaw, Jonathan M Monk, Elizabeth eBrunk, Robert eLewis, Suh In Loh, Arti eMishra, Amrita Abhay Nagle, Chitkala eSatyanarayana, Saravanakumar eDhakshinamoorthy, Michele eLuche, Douglas B Kitchen, Kathleen A Andrews, Bernhard O Palsson, Pep eCharusanti
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Microbiology
Subjects:
Drug Discovery
Systems Biology
bacterial metabolism
synthetic lethality
metabolic reconstruction
Antibiotic development
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00958/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00958/full

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