A Naturally-Occurring Dominant-Negative Inhibitor of Keap1 Competitively against Its Negative Regulation of Nrf2

A Naturally-Occurring Dominant-Negative Inhibitor of Keap1 Competitively against Its Negative Regulation of Nrf2

Transcription factor Nrf2 (nuclear factor-erythroid 2-related factor 2) is a master regulator of antioxidant and/or electrophile response elements (AREs/EpREs)-driven genes involved in homeostasis, detoxification, and adaptation to various stresses. The cytoprotective activity of Nrf2, though being...

Full description

Bibliographic Details
Main Authors: Lu Qiu, Meng Wang, Yuping Zhu, Yuancai Xiang, Yiguo Zhang
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
Keap1
Nrf2
Keap1ΔC
alternative splicing
redox stress
Online Access:http://www.mdpi.com/1422-0067/19/8/2150

Internet

http://www.mdpi.com/1422-0067/19/8/2150

Similar Items