KLHL1 Controls CaV3.2 Expression in DRG Neurons and Mechanical Sensitivity to Pain

KLHL1 Controls CaV3.2 Expression in DRG Neurons and Mechanical Sensitivity to Pain

Dorsal root ganglion (DRG) neurons process pain signaling through specialized nociceptors located in their peripheral endings. It has long been established low voltage-activated (LVA) CaV3.2 calcium channels control neuronal excitability during sensory perception in these neurons. Silencing CaV3.2 a...

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Bibliographic Details
Main Authors: Elizabeth Martínez-Hernández, Alissa Zeglin, Erik Almazan, Paula Perissinotti, Yungui He, Michael Koob, Jody L. Martin, Erika S. Piedras-Rentería
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
voltage-gated calcium channel
T-type channel
mechanical sensitivity
pain control
KLHL1
CaV3.2
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00315/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00315/full

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