Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair

Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair

Summary: Colorectal cancer (CRC) onset is profoundly affected by Western diet. Here, we report that high-fat (HF) diet-induced, organ-specific colonic lysine homocysteinylation (K-Hcy) increase might promote CRC onset by impeding DNA damage repair. HF chow induced elevated methionyl-tRNA synthetase...

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Bibliographic Details
Main Authors: Dan Wang, Rui Zhao, Yuan-Yuan Qu, Xin-Yu Mei, Xuan Zhang, Qian Zhou, Yang Li, Shao-Bo Yang, Zhi-Gui Zuo, Yi-Ming Chen, Yan Lin, Wei Xu, Chao Chen, Shi-Min Zhao, Jian-Yuan Zhao
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718314529

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http://www.sciencedirect.com/science/article/pii/S2211124718314529

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