The gateway theory: bridging neural and immune interactions in the CNS

The gateway theory: bridging neural and immune interactions in the CNS

The central nervous system (CNS) is considered an immune-privileged tissue protected by a specific vessel structure, the brain-blood barrier (BBB). Upon infection or traumatic injury in the CNS, the BBB is breached, and various immune cells are recruited to the affected area. In the case of autoimmu...

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Bibliographic Details
Main Authors: Daisuke eKamimura, Moe eYamada, Masaya eHarada, Lavannya eSabharwal, Meng eJie, Hidenori eBando, Hideki eOgura, Toru eAtsumi, Yasunobu eArima, Masaaki eMurakami
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Neuroscience
Subjects:
Autoimmune Diseases
Blood-Brain Barrier
Inflammation
Multiple Sclerosis
cytokine
Experimental autoimmune encephalomyelitis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00204/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00204/full

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