HIV-1 Tat Protein Enters Dysfunctional Endothelial Cells via Integrins and Renders Them Permissive to Virus Replication

HIV-1 Tat Protein Enters Dysfunctional Endothelial Cells via Integrins and Renders Them Permissive to Virus Replication

Previous work has shown that the Tat protein of Human Immunodeficiency Virus (HIV)-1 is released by acutely infected cells in a biologically active form and enters dendritic cells upon the binding of its arginine-glycine-aspartic acid (RGD) domain to the α5β1, αvβ3, and αvβ5 integrins. The up-regula...

Full description

Bibliographic Details
Main Authors: Aurelio Cafaro, Giovanni Barillari, Sonia Moretti, Clelia Palladino, Antonella Tripiciano, Mario Falchi, Orietta Picconi, Maria Rosaria Pavone Cossut, Massimo Campagna, Angela Arancio, Cecilia Sgadari, Claudia Andreini, Lucia Banci, Paolo Monini, Barbara Ensoli
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
integrins
endothelial cells
inflammatory cytokines
HIV-1 Tat protein
cellular uptake
HIV-1 target cells
Online Access:https://www.mdpi.com/1422-0067/22/1/317

Internet

https://www.mdpi.com/1422-0067/22/1/317

Similar Items