CBP/p300 HAT maintains the gene network critical for β cell identity and functional maturity

CBP/p300 HAT maintains the gene network critical for β cell identity and functional maturity

Abstract Loss of β cell identity and functional immaturity are thought to be involved in β cell failure in type 2 diabetes. CREB-binding protein (CBP) and its paralogue p300 act as multifunctional transcriptional co-activators and histone acetyltransferases (HAT) with extensive biological functions....

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Bibliographic Details
Main Authors: Linlin Zhang, Chunxiang Sheng, Feiye Zhou, Kecheng Zhu, Shushu Wang, Qianqian Liu, Miaomiao Yuan, Zhaoqian Xu, Yun Liu, Jieli Lu, Jianmin Liu, Libin Zhou, Xiao Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03761-1

Internet

https://doi.org/10.1038/s41419-021-03761-1

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