Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis

Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis

ALS is a devastating neurodegenerative disorder for which no effective treatment exists. Multiple molecular mechanisms are involved in the pathogenesis. We tested the catalytic antioxidant AEOL 10150, the histone deacetylase inhibitor phenylbutyrate (PBA), and the combination of PBA and AEOL 10150 i...

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Bibliographic Details
Main Authors: Susanne Petri, Mahmoud Kiaei, Khatuna Kipiani, Junyu Chen, Noel Y. Calingasan, John P. Crow, M. Flint Beal
Format: Article
Language:English
Published: Elsevier 2006-04-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Oxidative stress
Histone acetylation
Apoptosis
G93A transgenic mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002706

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http://www.sciencedirect.com/science/article/pii/S0969996105002706

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