Trabectedin and Lurbinectedin Extend Survival of Mice Bearing C26 Colon Adenocarcinoma, without Affecting Tumor Growth or Cachexia

Trabectedin and Lurbinectedin Extend Survival of Mice Bearing C26 Colon Adenocarcinoma, without Affecting Tumor Growth or Cachexia

Trabectedin (ET743) and lurbinectedin (PM01183) limit the production of inflammatory cytokines that are elevated during cancer cachexia. Mice carrying C26 colon adenocarcinoma display cachexia (i.e., premature death and body wasting with muscle, fat and cardiac tissue depletion), high levels of infl...

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Bibliographic Details
Main Authors: Giorgio Aquila, Andrea David Re Cecconi, Mara Forti, Roberta Frapolli, Ezia Bello, Deborah Novelli, Ilaria Russo, Simonetta Andrea Licandro, Lidia Staszewsky, Giulia Benedetta Martinelli, Laura Talamini, Laura Pasetto, Andrea Resovi, Raffaella Giavazzi, Eugenio Scanziani, Giorgia Careccia, Emilie Vénéreau, Serge Masson, Roberto Latini, Maurizio D’Incalci, Rosanna Piccirillo
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
cancer cachexia
muscle atrophy
lurbinectedin
trabectedin
inflammation
splenomegaly
Online Access:https://www.mdpi.com/2072-6694/12/8/2312

Internet

https://www.mdpi.com/2072-6694/12/8/2312

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