Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation

Mutations within the membrane domain of HMG-CoA reductase confer resistance to sterol-accelerated degradation

The pivotal event for sterol-induced degradation of the cholesterol biosynthetic enzyme HMG-CoA reductase is binding of its membrane domain to Insig proteins in the endoplasmic reticulum. Insigs are carriers for gp78, an E3 ubiquitin ligase that marks reductase for proteasomal degradation. We report...

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Bibliographic Details
Main Authors: Peter C.W. Lee, Andrew D. Nguyen, Russell A. DeBose-Boyd
Format: Article
Language:English
Published: Elsevier 2007-02-01
Series:Journal of Lipid Research
Subjects:
cholesterol homeostasis
endoplasmic reticulum-associated degradation
ubiquitination
somatic cell genetics
mutagenesis
membrane attachment region
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520436673

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http://www.sciencedirect.com/science/article/pii/S0022227520436673

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