Akt1 Stimulates Homologous Recombination Repair of DNA Double-Strand Breaks in a Rad51-Dependent Manner

Akt1 Stimulates Homologous Recombination Repair of DNA Double-Strand Breaks in a Rad51-Dependent Manner

Akt1 is known to promote non-homologous end-joining (NHEJ)-mediated DNA double-strand break (DSB) repair by stimulation of DNA-PKcs. In the present study, we investigated the effect of Akt1 on homologous recombination (HR)-dependent repair of radiation-induced DSBs in non-small cell lung cancer (NSC...

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Bibliographic Details
Main Authors: Katharina Mueck, Simone Rebholz, Mozhgan Dehghan Harati, H. Peter Rodemann, Mahmoud Toulany
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:International Journal of Molecular Sciences
Subjects:
homologous recombination
Akt1
Rad51
DNA double-strand break repair
non-small cell lung cancer
Online Access:https://www.mdpi.com/1422-0067/18/11/2473

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https://www.mdpi.com/1422-0067/18/11/2473

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