Low Molecular Weight pDMAEMA-block-pHEMA Block-Copolymers Synthesized via RAFT-Polymerization: Potential Non-Viral Gene Delivery Agents?

Low Molecular Weight pDMAEMA-block-pHEMA Block-Copolymers Synthesized via RAFT-Polymerization: Potential Non-Viral Gene Delivery Agents?

The aim of this study was to investigate non-viral pDNA carriers based on diblock-copolymers consisting of poly(2-(dimethyl amino)ethyl methacrylate) (pDMAEMA) and poly(2-hydroxyethyl methacrylate) (pHEMA). Specifically the block-lengths and molecular weights were varied to determine the minimal req...

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Bibliographic Details
Main Authors: Thomas Kissel, Christian Pfeiffer, Olga Samsonova, Markus Hellmund, Olivia M. Merkel
Format: Article
Language:English
Published: MDPI AG 2011-03-01
Series:Polymers
Subjects:
low molecular pDMAEMA
linear pDMAEMA-block-pHEMA diblock copolymers
RAFT-polymerization
poly(2-(dimethyl amino) ethyl methacrylate)
poly(2-hydroxyethylmethacrylate)
physico-chemical characterization
in vitro pDNA transfection
cytotoxicity
Online Access:http://www.mdpi.com/2073-4360/3/2/693/

Internet

http://www.mdpi.com/2073-4360/3/2/693/

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