High throughput phenotypic selection of Mycobacterium tuberculosis mutants with impaired resistance to reactive oxygen species identifies genes important for intracellular growth.

High throughput phenotypic selection of Mycobacterium tuberculosis mutants with impaired resistance to reactive oxygen species identifies genes important for intracellular growth.

Mycobacterium tuberculosis has the remarkable capacity to survive within the hostile environment of the macrophage, and to resist potent antibacterial molecules such as reactive oxygen species (ROS). Thus, understanding mycobacterial resistance mechanisms against ROS may contribute to the developmen...

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Bibliographic Details
Main Authors: Olga Mestre, Raquel Hurtado-Ortiz, Tiago Dos Vultos, Amine Namouchi, Mena Cimino, Madalena Pimentel, Olivier Neyrolles, Brigitte Gicquel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3540035?pdf=render

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http://europepmc.org/articles/PMC3540035?pdf=render

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