EphB2 Deficiency Induces Depression-Like Behaviors and Memory Impairment: Involvement of NMDA 2B Receptor Dependent Signaling

EphB2 Deficiency Induces Depression-Like Behaviors and Memory Impairment: Involvement of NMDA 2B Receptor Dependent Signaling

Receptor tyrosine kinase EphB2 mediates development of the neurogenic niche of excitatory neurons, suggesting the possibility that its inactivation plays a role in neuropsychiatric disorders including depression and memory impairment. While N-methyl-D-aspartate (NMDA) receptor is involved in regulat...

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Bibliographic Details
Main Authors: Linlin Zhen, Tuo Shao, Victor Luria, Gaowen Li, Zhi Li, Ying Xu, Xin Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
EphB2
depression
cognition
neurogenesis
NMDA-2B receptor
NR2B antagonist Ro25-6981
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00862/full

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https://www.frontiersin.org/article/10.3389/fphar.2018.00862/full

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