Marijuana-Derived Cannabinoids Trigger a CB2/PI3K Axis of Suppression of the Innate Response to Oral Pathogens

Marijuana-Derived Cannabinoids Trigger a CB2/PI3K Axis of Suppression of the Innate Response to Oral Pathogens

Cannabis use is an emergent risk factor for periodontitis, a chronic bacterial-induced disease of the supporting structures of the teeth. However, the mechanisms by which marijuana exposure predisposes to periodontal tissue destruction have yet to be elucidated. Therefore, we examined the influence...

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Bibliographic Details
Main Authors: Zhen Gu, Shilpa Singh, Rajarshi G. Niyogi, Gwyneth J. Lamont, Huizhi Wang, Richard J. Lamont, David A. Scott
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
cannabinoid receptor type 1 and 2 (CB1, CB2)
cholinergic anti-inflammatory system
glycogen synthase kinase (GSK3β)
inflammation
oral bacteria
phosphatidylinositol 3-phosphate-kinase (PI3K)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02288/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02288/full

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