IFN-γ-induced ER stress impairs autophagy and triggers apoptosis in lung cancer cells

IFN-γ-induced ER stress impairs autophagy and triggers apoptosis in lung cancer cells

Interferon-gamma (IFN-γ) is a major effector molecule of immunity and a common feature of tumors responding to immunotherapy. Active IFN-γ signaling can directly trigger apoptosis and cell cycle arrest in human cancer cells. However, the mechanisms underlying these actions remain unclear. Here, we r...

Full description

Bibliographic Details
Main Authors: Can Fang, Tao Weng, Shaojie Hu, Zhiwei Yuan, Hui Xiong, Bing Huang, Yixin Cai, Lequn Li, Xiangning Fu
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
ifn-γ
lung adenocarcinoma
er stress
lamp
autophagy
apoptosis
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1962591

Internet

http://dx.doi.org/10.1080/2162402X.2021.1962591

Similar Items