Prognostic significance of BRAF and NRAS mutations in melanoma: a German study from routine care

Prognostic significance of BRAF and NRAS mutations in melanoma: a German study from routine care

Abstract Background Hotspot mutations of the oncogenes BRAF and NRAS are the most common genetic alterations in cutaneous melanoma. Specific inhibitors of BRAF and MEK have shown significant survival benefits in large phase III trials. However, the prognostic significance of BRAF and NRAS mutations...

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Bibliographic Details
Main Authors: Markus V. Heppt, Timo Siepmann, Jutta Engel, Gabriele Schubert-Fritschle, Renate Eckel, Laura Mirlach, Thomas Kirchner, Andreas Jung, Anja Gesierich, Thomas Ruzicka, Michael J. Flaig, Carola Berking
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Cancer
Subjects:
Melanoma
BRAF
NRAS
BRAF inhibitor
MEK inhibitor
Immune checkpoint blockade
Online Access:http://link.springer.com/article/10.1186/s12885-017-3529-5

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http://link.springer.com/article/10.1186/s12885-017-3529-5

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