Paroxysmal nocturnal hemoglobinuria: When delay in diagnosis and long therapy occurs

Paroxysmal nocturnal hemoglobinuria: When delay in diagnosis and long therapy occurs

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal disorder characterized by hemolytic anemia, bone marrow failure and thrombosis, caused by a somaticmutation in PIG-A gene that results in theabsence of CD55 and CD59, two important complement regulatory proteins. In thispaper, a case of PNH...

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Bibliographic Details
Main Authors: Salvatrice Mancuso, Giuseppe Sucato, Melania Carlisi, Marco Santoro, Giuseppe Tarantino, Emilio Iannitto, Mariasanta Napolitano, Sergio Siragusa
Format: Article
Language:English
Published: PAGEPress Publications 2018-03-01
Series:Hematology Reports
Subjects:
paroxysmal nocturnal hemoglo-binuria, thrombotic events, renal failure, Eculizumab
Online Access:http://www.pagepress.org/journals/index.php/hr/article/view/7523

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http://www.pagepress.org/journals/index.php/hr/article/view/7523

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