miR-214 ameliorates acute kidney injury via targeting DKK3 and activating of Wnt/β-catenin signaling pathway

Abstract Background miR-214 was demonstrated to be upregulated in models of renal disease and promoted fibrosis in renal injury independent of TGF-β signaling in vivo. However, the detailed role of miR-214 in acute kidney injury (AKI) and its underlying mechanism are still largely unknown. Methods I...

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Bibliographic Details
Main Authors: Xiaoguang Zhu, Wenwen Li, Huicong Li
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Biological Research
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40659-018-0179-2