Pharmacokinetics of Macrolide Antibiotics and Transport into the Interstitial Fluid: Comparison among Erythromycin, Clarithromycin, and Azithromycin

Recent research has found higher levels and longer total exposure of azithromycin, a macrolide antibiotic agent, in the interstitial fluid of the skin than in the plasma. This unique distribution is expected to contribute to its antimicrobial activity at the primary infection site. However, it remai...

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Bibliographic Details
Main Authors: Shinji Kobuchi, Teruhiko Kabata, Koki Maeda, Yukako Ito, Toshiyuki Sakaeda
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Antibiotics
Subjects:
Online Access:https://www.mdpi.com/2079-6382/9/4/199