Modified age-dependent expression of NaV1.6 in an ALS model correlates with motor cortex excitability alterations

Modified age-dependent expression of NaV1.6 in an ALS model correlates with motor cortex excitability alterations

Cortical hyperexcitability is an early and intrinsic feature of Amyotrophic Lateral Sclerosis (ALS), but the mechanisms underlying this critical neuronal dysfunction are poorly understood. Recently, we have demonstrated that layer V pyramidal neurons (PNs) in the primary motor cortex (M1) of one-mon...

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Bibliographic Details
Main Authors: Luana Saba, Maria Teresa Viscomi, Alessandro Martini, Silvia Caioli, Nicola Biagio Mercuri, Ezia Guatteo, Cristina Zona
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
ALS
G93A
Electrophysiology
Neuronal excitability
Persistent Na+ current
NaV1.6
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119302001

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http://www.sciencedirect.com/science/article/pii/S0969996119302001

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