MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone.

MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone.

Cilia have a unique diffusion barrier ("gate") within their proximal region, termed transition zone (TZ), that compartmentalises signalling proteins within the organelle. The TZ is known to harbour two functional modules/complexes (Meckel syndrome [MKS] and Nephronophthisis [NPHP]) defined...

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Bibliographic Details
Main Authors: Chunmei Li, Victor L Jensen, Kwangjin Park, Julie Kennedy, Francesc R Garcia-Gonzalo, Marta Romani, Roberta De Mori, Ange-Line Bruel, Dominique Gaillard, Bérénice Doray, Estelle Lopez, Jean-Baptiste Rivière, Laurence Faivre, Christel Thauvin-Robinet, Jeremy F Reiter, Oliver E Blacque, Enza Maria Valente, Michel R Leroux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-03-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1002416

Internet

https://doi.org/10.1371/journal.pbio.1002416

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