MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1.

MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1.

The Ca(2+) sensor S100A1 is essential for proper endothelial cell (EC) nitric oxide (NO) synthase (eNOS) activation. S100A1 levels are greatly reduced in primary human microvascular ECs subjected to hypoxia, rendering them dysfunctional. However mechanisms that regulate S100A1 levels in ECs are unkn...

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Bibliographic Details
Main Authors: Anagha Sen, Shumei Ren, Carolin Lerchenmüller, Jianxin Sun, Norbert Weiss, Patrick Most, Karsten Peppel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3823839?pdf=render

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http://europepmc.org/articles/PMC3823839?pdf=render

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